What is PDRN? The K-beauty ingredient, explained

What does PDRN stand for?

PDRN is short for polydeoxyribonucleotide. It's a long name for a refined skincare ingredient made from short fragments of DNA.

On an ingredient list, PDRN usually appears as sodium DNA. You'll find it in serums, ampoules, creams and sheet masks, often alongside hydrating ingredients like glycerin and hyaluronic acid.

Where does PDRN come from?

Traditionally, PDRN is sourced from salmon DNA, which is why you'll hear PDRN products called "salmon serums." The DNA is extracted and purified into a refined ingredient before it goes into a formula.

Plant-based versions also exist, sometimes sold as "phyto-PDRN." These use DNA-like material from plants such as ginseng. Brands don't use these labels consistently, so the ingredient list and the brand's sourcing notes are your best guide.

We'll confirm the source of the PDRN in our PDRN + Retinol Night Serum on its full ingredient list at launch.

Why is everyone talking about PDRN?

PDRN rose to fame in Korea, where it became a signature of the "glass skin" look: skin that appears smooth, bouncy and lit from within. As K-beauty went global, PDRN followed, and it has become one of the buzziest ingredients in skincare.

Part of the appeal is texture. PDRN formulas tend to feel light and hydrating, and they layer easily under moisturizer.

What will you notice?

In a well-made formula, PDRN is part of the recipe for a bouncy, well-hydrated, healthy-looking finish. Skin can look plumper and feel softer, especially when PDRN is paired with good hydrators.

As with any skincare ingredient, results come from the whole formula and from consistent use, not from one ingredient on its own.

How to use PDRN in your routine

1. 1

   Step 1: Cleanse

   Start with clean skin and pat it dry with a towel.

2. 2

   Step 2: Apply your PDRN serum

   Smooth a few drops or a pea-size amount over your face and neck. Serums go on before creams.

3. 3

   Step 3: Moisturize

   Follow with a moisturizer to keep hydration in. In the morning, finish with sunscreen.

PDRN plays well with most routines. It's commonly paired with hyaluronic acid, niacinamide, ceramides and peptides. Introduce any new product on its own first so you can see how your skin likes it.

Can you use PDRN with retinol?

Yes. PDRN and retinol are a natural night-time pair: retinol for smoothing the look of fine lines and texture, PDRN for a bouncy, hydrated look. Our guide to using PDRN and retinol together covers how to layer them, or you can keep it simple with a two-in-one serum like our PDRN + Retinol Night Serum.